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consists of Chlorphenamine, Dexamethasone.

Chlorphenamine (Phenadone)

Uses of Chlorphenamine :

What are some things I need to know or do while I take Chlorphenamine ?

Chlorphenamine (Phenadone) side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Chlorphenamine (Phenadone) other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Dexamethasone (Phenadone)

What is Dexamethasone (Phenadone)

Dexamethasone (Phenadone) is a steroid that prevents the release of substances in the body that cause inflammation.
Dexamethasone (Phenadone) is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, breathing disorders, inflammatory eye conditions, blood cell disorders, leukemia, or endocrine disorders.
Dexamethasone (Phenadone) may also be used for purposes not listed in Dexamethasone (Phenadone) guide.

How is Dexamethasone injection given?

Dexamethasone (Phenadone) is often injected into a muscle or into a vein through an IV. A healthcare provider will give you this injection. Dexamethasone (Phenadone) injection is usually given for only a few days.
Your dosage needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.
Dexamethasone (Phenadone) can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Dexamethasone (Phenadone).
After your treatment ends, you may have withdrawal symptoms such as fever, weakness, and joint or muscle pain. You should not stop using Dexamethasone (Phenadone) suddenly.

What should I avoid after receiving Dexamethasone?

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using a steroid.
Do not receive a "live" vaccine while using Dexamethasone (Phenadone). Steroids may increase your risk of harmful effects from a live vaccine. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Dexamethasone (Phenadone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Dexamethasone (Phenadone) dosing

Usual Adult Dose for Acute Mountain Sickness:

Oral, IV and IM :
0.75 to 9 mg per day in divided doses every 6 to 12 hours
IM (as acetate):
8 to 16 mg, may repeat in 1 to 3 weeks
Intralesional (as acetate):
0.8 to 1.6 mg
Intraarticular and soft tissue as acetate):
4 to 16 mg, may repeat in 1 to 3 weeks
Intraarticular, intralesional, or soft tissue (as sodium phosphate):
0.4 to 6 mg per day

Usual Adult Dose for Asthma -- Acute:

Oral, IV and IM (injections as sodium phosphate):
0.75 to 9 mg per day in divided doses every 6 to 12 hours
IM (as acetate):
8 to 16 mg, may repeat in 1 to 3 weeks
Intralesional (as acetate):
0.8 to 1.6 mg
Intraarticular and soft tissue as acetate):
4 to 16 mg, may repeat in 1 to 3 weeks
Intraarticular, intralesional, or soft tissue (as sodium phosphate):
0.4 to 6 mg per day

Usual Adult Dose for Croup:

Oral, IV and IM :
0.75 to 9 mg per day in divided doses every 6 to 12 hours
IM (as acetate):
8 to 16 mg, may repeat in 1 to 3 weeks
Intralesional (as acetate):
0.8 to 1.6 mg
Intraarticular and soft tissue as acetate):
4 to 16 mg, may repeat in 1 to 3 weeks
Intraarticular, intralesional, or soft tissue (as sodium phosphate):
0.4 to 6 mg per day

Usual Adult Dose for Anti-inflammatory:

Oral, IV and IM (injections as sodium phosphate):
0.75 to 9 mg per day in divided doses every 6 to 12 hours
IM (as acetate):
8 to 16 mg, may repeat in 1 to 3 weeks
Intralesional (as acetate):
0.8 to 1.6 mg
Intraarticular and soft tissue as acetate):
4 to 16 mg, may repeat in 1 to 3 weeks
Intraarticular, intralesional, or soft tissue (as sodium phosphate):
0.4 to 6 mg per day

Usual Adult Dose for Cerebral Edema:

Initial 10 mg IV once, followed by 4 mg IM every 6 hours until symptoms of cerebral edema subside. Dosage may be reduced after 2 to 4 days, and discontinued slowly over a period of 5 to 7 days.

Usual Adult Dose for Cushing's Syndrome:

Suppression test or diagnosis for Cushing's syndrome:
1 mg orally at 11 p.m. Blood plasma cortisol measurement at 8 a.m. the next morning.
or
0.5 mg by mouth every 6 hours for 48 hours.
Differentiation of Cushing's syndrome due to ACTH excess from Cushing's due to other causes: Oral: Dexamethasone (Phenadone) 2 mg every 6 hours for 48 hours (with 24 hour urine collection for 17 hydroxycorticosteroid excretion).

Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:

Prophylaxis:
10 mg to 20 mg orally or IV, 15 to 30 minutes before treatment on each treatment day
For continuous infusion of chemotherapy:
10 mg orally or IV every 12 hours on each treatment day.
For mildly emetogenic therapy: 4 mg oral, IV or IM every 4 to 6 hours.
Delayed nausea and vomiting:
8 mg orally every 12 hours for 2 days; then 4 mg every 12 hours for 2 days.
or
20 mg orally 1 hour before chemotherapy; then 10 mg orally 12 hours after chemotherapy; then 8 mg orally every 12 hours for 4 doses; then 4 mg orally every 12 hours for 4 doses.

Usual Adult Dose for Shock:

Addisonian crisis/shock:
4 to 10 mg IV as single dose, repeat if necessary.
Unresponsive shock:
1 to 6 mg/kg IV as a single dose or up to 40 mg initially followed by repeat doses every 2 to 6 hours while shock persists.

Usual Adult Dose for Multiple Myeloma:

Multiple myeloma: Oral, IV: 40 mg/day, days 1 to 4, 9 to 12, and 17 to 20, repeated every 4 weeks.

Usual Adult Dose for Multiple Sclerosis:

Multiple sclerosis (acute exacerbation): Oral: 30 mg/day for 1 week, followed by 4 to 12 mg/day for 1 month.

Usual Adult Dose for Adrenal Insufficiency:

Physiological replacement: Oral, IM, IV : 0.03 to 0.15 mg/kg/day or 0.6 to 0.75 mg/m2/day in divided doses every 6 to 12 hours.

Usual Pediatric Dose for Cerebral Edema:

Initial loading dose: 1 to 2 mg/kg once orally, IV or IM.
Maintenance: 1 to 1.5 mg /kg/day, give in divided doses every 4 to 6 hours for 5 days then taper for 5 days, then discontinue. Maximum dose: 16 mg/day.

Usual Pediatric Dose for Meningitis -- Meningococcal:

:
Meningitis (H. influenzae type b): Infants and Children 6 weeks or older: IV: 0.15 mg/kg/dose every 6 hours for the first 2 to 4 days of antibiotic treatment; start Dexamethasone (Phenadone) 10 to 20 minutes before or with the first dose of antibiotic. If antibiotics have already been administered, Dexamethasone (Phenadone) use has not been shown to improve patient outcome and is not recommended. Note: For pneumococcal meningitis, data has not shown clear benefit from Dexamethasone (Phenadone) administration; risk and benefits should be considered prior to use.

Usual Pediatric Dose for Meningitis -- Haemophilus influenzae:

(Not approved by FDA):
Meningitis (H. influenzae type b): Infants and Children 6 weeks or older: IV: 0.15 mg/kg/dose every 6 hours for the first 2 to 4 days of antibiotic treatment; start Dexamethasone (Phenadone) 10 to 20 minutes before or with the first dose of antibiotic. If antibiotics have already been administered, Dexamethasone (Phenadone) use has not been shown to improve patient outcome and is not recommended. Note: For pneumococcal meningitis, data has not shown clear benefit from Dexamethasone (Phenadone) administration; risk and benefits should be considered prior to use.

Usual Pediatric Dose for Meningitis -- Pneumococcal:

:
Meningitis (H. influenzae type b): Infants and Children 6 weeks or older: IV: 0.15 mg/kg/dose every 6 hours for the first 2 to 4 days of antibiotic treatment; start Dexamethasone (Phenadone) 10 to 20 minutes before or with the first dose of antibiotic. If antibiotics have already been administered, Dexamethasone (Phenadone) use has not been shown to improve patient outcome and is not recommended. Note: For pneumococcal meningitis, data has not shown clear benefit from Dexamethasone (Phenadone) administration; risk and benefits should be considered prior to use.

Usual Pediatric Dose for Meningitis - Listeriosis:

(Not approved by FDA):
Meningitis (H. influenzae type b): Infants and Children 6 weeks or older: IV: 0.15 mg/kg/dose every 6 hours for the first 2 to 4 days of antibiotic treatment; start Dexamethasone (Phenadone) 10 to 20 minutes before or with the first dose of antibiotic. If antibiotics have already been administered, Dexamethasone (Phenadone) use has not been shown to improve patient outcome and is not recommended. Note: For pneumococcal meningitis, data has not shown clear benefit from Dexamethasone (Phenadone) administration; risk and benefits should be considered prior to use.

Usual Pediatric Dose for Anti-inflammatory:

0.08 to 0.3 mg/kg/day or 2.5 to 5 mg/m2/day in divided doses every 6 to 12 hours.

Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced:

:
Prior to chemotherapy:
10 mg/meter squared IV for first dose (maximum 20 mg) then 5 mg/meter squared/dose every 6 hours as needed.

Usual Pediatric Dose for Asthma -- Acute:

Asthma exacerbation: Oral, IM, IV: 0.6 mg/kg once (maximum dose: 16 mg)

Usual Pediatric Dose for Croup:

:
Croup (laryngotracheobronchitis): Oral, IM, IV: 0.6 mg/kg once (maximum: 20 mg). A single dose of 0.15 mg/kg has also been shown effective.

Usual Pediatric Dose for Adrenal Insufficiency:

Physiological replacement: Oral, IM, IV (should be given as sodium phosphate): 0.03 to 0.15 mg/kg/day or 0.6 to 0.75 mg/m2/day in divided doses every 6 to 12 hours.

Usual Pediatric Dose for Acute Mountain Sickness:

:
Acute mountain sickness (AMS)/high altitude cerebral edema (HACE); treatment: Oral, IM, IV: 0.15 mg/kg/dose every 6 hours; consider using for high altitude pulmonary edema because of associated HACE with this condition.

Usual Pediatric Dose for Bronchopulmonary Dysplasia:

(Not approved by FDA):
Bronchopulmonary dysplasia, facilitation of ventilator wean: postnatal age =7 days: Oral, IV: Initial: 0.15 mg/kg/day given in divided doses every 12 hours for 3 days, then tapered every 3 days over 7 days; total Dexamethasone (Phenadone) dose: 0.89 mg/kg given over 10 days; others have used 0.2 mg/kg/day given once daily and tapered every 3 days over 7 days (total Dexamethasone (Phenadone) dose: 1 mg/kg) ( or tapered over 14 days (total Dexamethasone (Phenadone) dose: 1.9 mg/kg). Note: High doses (0.5 mg/kg/day) do not confer additional benefit over lower doses, are associated with higher incidence of adverse effects (including adverse neurodevelopmental outcomes), and are not recommended for use. However, a meta-analysis reported total cumulative doses greater than 4 mg/kg reduced the relative risk for the combined outcome, mortality, or bronchopulmonary dysplasia; further studies are needed.


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References

  1. Dailymed."Dexamethasone: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Dexamethasone". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "Dexamethasone". http://www.drugbank.ca/drugs/DB0123... (accessed August 28, 2018).

Phenadone - Frequently asked Questions

Can Phenadone be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

How should I take Dexamethasone (Phenadone)?

You should not use this medication if you have a fungal infection anywhere in your body.

How should I take Chlorphenamine (Phenadone)?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

What do I do if I miss a dose?

What other drugs will affect Dexamethasone (Phenadone)?

Many drugs can interact with Dexamethasone (Phenadone). This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Dexamethasone (Phenadone). Give a list of all your medicines to any healthcare provider who treats you.

Who should not take Dexamethasone (Phenadone)?

You should not use this medication if you are allergic to Dexamethasone (Phenadone) or sulfites, or if you have a fungal infection anywhere in your body.

Steroid medication can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Before using this medication, tell your doctor about any illness or infection you have had within the past several weeks.

To make sure Dexamethasone (Phenadone) is safe for you, tell your doctor if you have:

FDA pregnancy category C. It is not known whether Dexamethasone (Phenadone) will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Dexamethasone (Phenadone) can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Steroids can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

Who should not take Chlorphenamine (Phenadone)?

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Can Phenadone be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Phenadone be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on Phenadone, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Phenadone. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

Patient reports

Two patients reported useful

How active was the Phenadone in relieving patients of the disease or symptoms?
Based on the survey reports from users of gmedication.com, about Useful percentage of users claimed the Phenadone were useful to them in reducing their symptoms and diseases. However, the effectiveness of the medicine is influenced by many factors like the perception of the symptom, the severity of the conditions, and some other factors; the brand name could also be a factor to an extent. In the event the medicine does not produce the same effective result in your case, ensure you consult your medical expert to reexamine you on your disease or symptoms and prescribe, after that, alternative medications.
Patients%
Useful2
100.0%


Four patients reported side effects

Does the Phenadone Have Any Side Effects?
Based on the survey report from users of gmedication.com, about No side effects number of people suffered some side effect after consumption of Phenadone. All drugs have a portion of undesirable side effects. These effects could be irritations too insignificant for the patient to even notice. However, the side effects of drugs may be determined by several factors like severity of disease and conditions associated with individual patients. However, one of the biggest factors is the dosage consumed. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. All patients have their different intensity of side effects. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Phenadone.
Patients%
No side effects4
100.0%


Patient reported price estimates

No survey data has been collected yet


Thirteen patients reported frequency of use

How often should I take Phenadone?
According to the survey, gmedication.com reported that users of Phenadone should take Twice in a day as the primarily recommended frequency. However, patients are advised to follow the dosage as prescribed by their physician religiously. To get the opinions of other patients on the ideal consumption frequency of the medicine, click here.
Patients%
Twice in a day8
61.5%
3 times in a day3
23.1%
Once in a day2
15.4%


Nine patients reported doses

What is the specific doses you have used?
Phenadone May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient's condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.
Patients%
6-10mg4
44.4%
1-5mg3
33.3%
201-500mg1
11.1%
101-200mg1
11.1%


Five patients reported time for results

How long will I use Phenadone before I begin to notice the effect?
According to the report by users of gmedication.com, about 5 days and a few days was the most common time duration among the participants, before they began to feel relief in their health conditions. It is noteworthy that you may not get the same result with other users within the same time frame. Several factors determine the timeframe; hence we implore you to consult your medical expert to get professional advice on how long you should expect to see improvement while consuming Phenadone. However, if you wish to get the response of other users on the time effectiveness of using Phenadone kindly click here
Patients%
5 days2
40.0%
1 week1
20.0%
> 3 month1
20.0%
3 month1
20.0%


Patient reported administration

No survey data has been collected yet


51 patients reported age

Patients%
1-525
49.0%
6-157
13.7%
46-606
11.8%
< 15
9.8%
30-455
9.8%
16-292
3.9%
> 601
2.0%


Patient reviews


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The information was verified by Dr. Vishal Pawar, MD Pharmacology