Naloxonum

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• Read drug prescription
• What is Naloxonum
• How is Naloxonum given?
• Naloxonum side effects
• Naloxonum dosing
• Select the most affordable brand or generic drug
• Frequently asked Questions
• Who should not take Naloxonum?
• How should I take Naloxonum?
• What other drugs will affect Naloxonum?
• Naloxonum reviews

Read drug prescription

What is Naloxonum

Naloxonum blocks or reverses the effects of opioid medication, including extreme drowsiness, slowed breathing, or loss of consciousness. An opioid is sometimes called a narcotic.
Naloxonum is used to treat a narcotic overdose in an emergency situation. This medicine should not be used in place of emergency medical care for an overdose.
Naloxonum is also used to help diagnose whether a person has used an overdose of an opioid.
Naloxonum may also be used for purposes not listed in Naloxonum guide.

How is Naloxonum given?

Naloxonum is injected into a muscle, under the skin, or into a vein through an IV. The injection may be given by a healthcare provider, emergency medical provider, or a family member or caregiver who is trained to properly give a Naloxonum injection.
If you are a caregiver or family member giving a Naloxonum injection, read all instructions when you first get this medicine. If provided, use the "trainer" device to practice giving an injection so you will know how to do it in an emergency. Ask your doctor or pharmacist if you have any questions.
Be sure you know how to recognize the signs of an opioid overdose in the person you are caring for. Overdose symptoms may include:

• slowed breathing, or no breathing;
• very small or pinpoint pupils in the eyes;
• slow heartbeats; or
• extreme drowsiness, especially if you are unable to wake the person from sleep.

Even if you are not sure an opioid overdose has occurred, if the person is not breathing or is unresponsive, give the Naloxonum injection right away and then seek emergency medical care.
Do not assume that an overdose episode has ended if symptoms improve. You must get emergency help after giving a Naloxonum injection.
Naloxonum injected into a muscle is given in the outer thigh. In an emergency, you may give an injection through the person's clothing.
After injecting Naloxonum, stay with the person and watch for continued signs of overdose. You may need to give another injection every 2 to 3 minutes until emergency help arrives. Follow all medication instructions carefully.
Each Naloxonum is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting a dose.
Store at room temperature away from moisture and heat. Keep the auto-injector in its outer case until you are ready to use it. Do not use the medicine if it has changed colors or has particles in it. Call your pharmacist for new medication.

Naloxonum side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Because Naloxonum reverses opioid effects, this medicine may cause sudden withdrawal symptoms such as:

• nausea, vomiting, diarrhea, stomach pain;
• fever, sweating, body aches, weakness;
• tremors or shivering, fast heart rate, pounding heartbeats, increased blood pressure;
• feeling nervous, restless, or irritable;
• goosebumps, shivering;
• runny nose, yawning; or
• seizures, crying, stiffness, overactive reflexes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Naloxonum dosing

Usual Adult Dose for Opioid Overdose:

Initial dose: 0.4 mg to 2 mg IV; alternatively, may give IM or subcutaneously
-If desired response is not obtained, doses should be repeated at 2 to 3 minute intervals
-If no response is observed with a total dose of 10 mg, the diagnosis of opioid-induced or partial opioid-induced toxicity should be questioned
Auto-injector: For emergency use in the home or other non-medical setting
-Administer 0.4 mg IM or subcutaneously into the anterolateral aspect of the thigh (through clothing if necessary)
-If desired response is not achieved, a second dose may be administered after 2 or 3 minutes; additional doses may be administered every 2 to 3 minutes until emergency medical assistance arrives
Nasal Spray:
-Administer 1 spray intranasally into 1 nostril
-If desired response is not achieved after 2 or 3 minutes, give a second dose intranasally into alternate nostril; additional doses may be administered every 2 to 3 minutes in alternating nostrils until emergency medical assistance arrives
Comments:
-IV route is recommended in emergency situations since it has the most rapid onset of action.
-The duration of action of some opioids exceed that of this drug, therefore, repeat doses may be needed; the need for repeat doses will depend on the amount, type, and route of administration of the opioid being antagonized.
-Patients should remain under continued surveillance; if a patients responds and relapses back into respiratory depression, additional doses should be given.
-Additional supportive and/or resuscitative measures may be helpful while awaiting emergency medical assistance.
Use: For the emergency treatment of known or suspected opioid overdose as manifested by respiratory and/or central nervous system depression.

Usual Adult Dose for Reversal of Opioid Sedation:

Initial dose: 0.1 to 0.2 mg IV at 2 to 3 minute intervals to the desired degree of reversal
-Supplemental doses administered IM have been shown to produce a longer lasting effect
Intravenous Infusion:
-A concentration of 0.004 mg/mL may be administered by IV infusion; titrate in accordance with patient's response
Comments:
-For the partial reversal of opioid depression following the use of opioids during surgery, smaller doses of Naloxonum are usually sufficient; larger than necessary doses may result in significant reversal of analgesia and increases in blood pressure.
Use: For the complete or partial reversal of opioid depression including respiratory depression, induced by natural and synthetic opioids and certain mixed agonist-antagonist analgesics.

Usual Pediatric Dose for Opioid Overdose:

Neonates:
Initial dose: 0.01 mg/kg IV, IM, or subcutaneously; repeat dose every 2 to 3 minutes as needed
Children:
Initial dose: 0.01 mg/kg IV; if desired response is not obtained, may give 0.1 mg/kg IV
-If IV route is not available may give IM or subcutaneously in divided doses
Auto-injector: For emergency use in the home or other non-medical setting
-Administer 0.4 mg IM or subcutaneously into the anterolateral aspect of the thigh (through clothing if necessary); if desired response is not achieved, a second dose may be administered after 2 or 3 minutes; additional doses may be administered every 2 to 3 minutes until emergency medical assistance arrives
-Under 1 year of age: Thigh muscle should be pinched while administering injection
Nasal Spray:
-Administer 1 spray intranasally into 1 nostril
-If desired response is not achieved after 2 or 3 minutes, give a second dose intranasally into alternate nostril; additional doses may be administered every 2 to 3 minutes in alternating nostrils until emergency medical assistance arrives
Comments:
-Neonatal opioid withdrawal syndrome may be life-threatening and should be treated according to protocols developed by neonatology experts.
- To avoid precipitating opioid withdrawal symptoms, consider use of a Naloxonum product that can be dosed according to weight and titrated to effect.
-The duration of action of some opioids will exceed that of this drug, therefore, repeat doses may be needed; the need for repeat doses will depend on the amount, type, and route of administration of the opioid being antagonized.
-Patients should remain under continued surveillance; if a patients responds and relapses back into respiratory depression, additional doses should be given.
-Additional supportive and/or resuscitative measures may be helpful while awaiting emergency medical assistance.
Use: For the emergency treatment of known or suspected opioid overdose as manifested by respiratory and/or central nervous system depression.

Usual Pediatric Dose for Reversal of Opioid Sedation:

Neonates:
Initial dose: 0.01 mg/kg IV, IM or subcutaneously at 2 to 3 minute intervals to the desired degree of reversal
Children: 0.005 mg to 0.01 mg IV at 2 to 3 minute intervals to the desired degree of reversal
Intravenous Infusion:
-A concentration of 0.004 mg/mL may be administered by IV infusion; titrate in accordance with patient's response
Comments:
-For the partial reversal of opioid depression following the use of opioids during surgery, smaller doses of Naloxonum are usually sufficient; larger than necessary doses may result in significant reversal of analgesia and increases in blood pressure.
Use: For the complete or partial reversal of opioid depression including respiratory depression, induced by natural and synthetic opioids and certain mixed agonist-antagonist analgesics.

Active ingredients: Naloxone

Select the most affordable brand or generic drug

Strength	Quantity	Price, USD	Country
Evzio
Evzio auto-injector
Feng Du
Grayxona
Jian Tian Neng
Jin Er Lun
Kawin Nuotong
Mapin
Naloxon DeltaSelect
Naloxon WZF Polfa
Naloxona
Naloxona B. Braun
Naloxona Denver
Naloxona Feparvi
Naloxona Gemepe
Naloxone Aguettant
Naloxone Amomed
Naloxone Dongkook
Naloxone Genovate
Naloxone HCl-Fresenius
Naloxone Hydrochlorid
Naloxone Hydrochloride DBL
Naloxone Hydrochloride Martindale
Naloxone Wockhardt
Naloxoni hydrochloridum
Naloxonum Hydrochloricum WZF
Naxan
Nexodal
Nokoba
Nokoba 0.4 mg/1 mL x 2 mL x 5's		$25.90
Oxogina
Prenoxad
Sai Xian
Su Nuo
Xin Pu Ao

References

1. "Naloxone". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
2. "Naloxone". http://www.drugbank.ca/drugs/DB0118... (accessed August 28, 2018).
3. "36b82amq7n: the unique ingredient identifier (unii) is an alphanumeric substance identifier from the joint fda/usp substance registration system (srs).". https://www.fda.gov/ForIndustry/Dat... (accessed August 28, 2018).

Naloxonum - Frequently asked Questions

Can Naloxonum be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

Who should not take Naloxonum?

You should not receive this medicine if you are allergic to Naloxonum.

To make sure Naloxonum is safe for you, tell your doctor if you have:

• heart disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether Naloxonum passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.

How should I take Naloxonum?

In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast feeding. Make sure any doctor caring for you afterward knows that you have received this medication.

What other drugs will affect Naloxonum?

Other drugs may interact with Naloxonum, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

See also: Side effects (in more detail)

Can Naloxonum be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Naloxonum be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on Naloxonum, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Naloxonum. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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The information was verified by Dr. Vishal Pawar, MD Pharmacology