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What is 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]

1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is a monoclonal antibody. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.
The 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] brand of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is not for use in people with multiple myeloma (bone marrow cancer).
1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is also used to treat giant cell bone tumor in adults and teenagers with fully matured bone structure.
1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is also used to treat high blood levels of calcium caused by cancer, when other medicines such as pamidronate or zoledronic acid (Zometa) have been used without success.
1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] guide provides information about the 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] brand of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]. 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is another brand of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] used to treat osteoporosis in postmenopausal women who have high risk of bone fracture.
1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] may also be used for purposes not listed in 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] guide.

How is 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] given?

1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is injected under the skin of your stomach, upper thigh, or upper arm. A healthcare provider will give you this injection.
1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is usually given once every 4 weeks. Follow your doctor's instructions.
Your doctor may have you take extra calcium and vitamin D while you are being treated with 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]. Take only the amount of calcium and vitamin D that your doctor has prescribed.
If you need to have any dental work, tell the dentist ahead of time that you are receiving 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]. You may need to stop using the medicine for a short time.
Pay special attention to your dental hygiene. Brush and floss your teeth regularly while receiving 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]. You may need to have a dental exam before you begin treatment with 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]. Follow your doctor's instructions.

1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] side effects

Get emergency medical help if you have any of these signs of an allergic reaction: itching, rash, hives; difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] dosing

Usual Adult Dose for Osteoporosis:

Prolia: 60 mg subcutaneously once every 6 months
Comments:
-If a dose is missed, the injection should be administered as soon as the patient is available. Thereafter, injections should be scheduled every 6 months from the date of the last injection.
Uses:
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Treatment to increase bone mass in men with osteoporosis
-Treatment of bone loss in men receiving androgen deprivation therapy for prostate cancer
-Treatment of bone loss in women receiving adjuvant aromatase inhibitor therapy for breast cancer

Usual Adult Dose for Giant Cell Tumor of Bone:

1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] (R): Initial dose: 120 mg subcutaneously on Days 8 and 15 of the first month of therapy in the upper arm, upper thigh, or abdomen
Maintenance dose: 120 mg subcutaneously every 4 weeks in the upper arm, upper thigh, or abdomen
Comments:
-Calcium and vitamin D should be administered to treat or prevent hypocalcemia.
Use: Treatment of adults and skeletally mature adolescents with giant cell tumor of bone that is unresectable or where surgical resection is likely to result in severe morbidity.

Usual Adult Dose for Osteolytic Bone Metastases of Solid Tumors:

Xgeva: 120 mg subcutaneously every 4 weeks
Comments:
-Calcium and vitamin D should be administered to treat or prevent hypocalcemia.
Use: Prevention of skeletal-related events in patients with bone metastases from solid tumors

Select the most affordable brand or generic drug


StrengthQuantityPrice, USDCountry
XGEVA 120MG INJECTION 1 vial(s) (1 injection each) $383.83Glaxo SmithKline Pharmaceuticals Ltd
Xgeva 120mg Injection $403.02Glaxo SmithKline Pharmaceuticals Ltd

References

  1. Dailymed."Prolia (denosumab) injection [amgen inc]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Denosumab". https://pubchem.ncbi.nlm.nih.gov/su... (accessed August 28, 2018).
  3. "Denosumab - drugbank". http://www.drugbank.ca/drugs/DB0664... (accessed August 28, 2018).

1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] - Frequently asked Questions

Can 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

How should I take 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]?

This medication guide provides information about the 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] brand of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]. 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is another brand of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] used to treat osteoporosis in postmenopausal women who have high risk of bone fracture.

You should not receive 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] if you have low levels of calcium in your blood.

What other drugs will affect 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]?

Other drugs may interact with 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia], including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Who should not take 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]?

You should not receive 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] if you are allergic to it or if you have low levels of calcium in your blood (hypocalcemia).

While you are receiving 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia], you should not use 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia], another brand of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia].

To make sure 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is safe for you, tell your doctor if you have kidney disease (or if you are on dialysis).

1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.

FDA pregnancy category D. Do not use 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] on the baby.

It is not known whether 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] passes into breast milk or if it could harm a nursing baby. However, this medication may slow the production of breast milk. You should not breast-feed while receiving 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia].

Can 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia], the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

Patient reports

Patient reported useful

No survey data has been collected yet


Patient reported side effects

No survey data has been collected yet


One patient reported price estimates

Do you think The Price of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] is Worth It?
Do you feel you paid higher than the value you got from it after usage? According to reports from gmedication.com users, on whether the 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] medicine is affordable, users shared different opinions on the question. The views concerning the price of the medicine were based on some factors like the brand the patient bought, the price compared to its level of effectiveness, the nation or country where the medicine is sold, and the amount of money the patient has. For users who are of the opinion that the medicine is unaffordable, they may have to consider a medicine with another brand in a bid to reduce cost.
Patients%
Expensive1
100.0%


One patient reported frequency of use

How often should I take 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]?
According to the survey, gmedication.com reported that users of 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] should take 3 times in a day as the primarily recommended frequency. However, patients are advised to follow the dosage as prescribed by their physician religiously. To get the opinions of other patients on the ideal consumption frequency of the medicine, click here.
Patients%
3 times in a day1
100.0%


Two patients reported doses

What is the specific doses you have used?
1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient's condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.
Patients%
101-200mg1
50.0%
1-5mg1
50.0%


Patient reported time for results

No survey data has been collected yet


Patient reported administration

No survey data has been collected yet


Five patients reported age

Patients%
> 603
60.0%
46-602
40.0%


Patient reviews


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The information was verified by Dr. Vishal Pawar, MD Pharmacology