XGEVA

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• Read drug prescription
• What is XGEVA
• Important safety information:
• XGEVA side effects
• Select the most affordable brand or generic drug
• Frequently asked Questions
• How should I take XGEVA?
• Who should not take XGEVA?
• XGEVA reviews

Read drug prescription

What is XGEVA

Preventing certain bone-related events in patients who have a certain type of tumor that has spread to the bones. It is also used to treat certain patients with giant-cell tumor of bone that cannot be removed by surgery. It is also used to treat high blood calcium levels in patients with cancer. It may also be used for other conditions as determined by your doctor.
XGEVA is a receptor activator of nuclear factor kappa B ligand (RANKL) inhibitor. It works by slowing bone loss and increasing bone strength. This helps to reduce the risk of bone-related events in patients with cancer that has spread to the bone.

Important safety information:

• Talk to your doctor about taking a calcium or vitamin D supplement while you use XGEVA.
• Tell your doctor or dentist that you take XGEVA before you receive any medical or dental care, emergency care, or surgery.
• XGEVA may cause jaw bone problems in some patients. Your risk may be greater if you have cancer, poor dental hygiene, ill-fitting dentures, or certain other conditions. Your risk may also be greater if you have certain dental procedures or you use certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before you start to use XGEVA. Ask your doctor any questions you may have about dental treatment while you use XGEVA.
• Proper dental care is important while you are taking XGEVA. Brush and floss your teeth and visit the dentist regularly.
• Certain dental procedures should be avoided if possible while you are using XGEVA. Check with your doctor and dentist before having any dental treatments while using XGEVA.
• Certain fractures of the thigh bone (femur) have been reported in patients using XGEVA. Some of these patients were also receiving glucocorticoids (eg, prednisone). Contact your doctor right away if you experience new or unusual hip, thigh, or groin pain. Discuss any questions or concerns with your doctor.
• Low calcium levels may occur from treatment with XGEVA. In severe cases, this can be deadly. Call your doctor right away if you have muscle stiffness, spasms, twitches, or cramps; burning, numbness, or tingling in your fingers, toes, or around your mouth; or seizures.
• It is not known how much of XGEVA is found in semen. Men who take XGEVA and have unprotected sex with a pregnant woman may expose XGEVA to the fetus. Discuss any questions or concerns with your doctor.
• If you are able to become pregnant, you must use effective birth control while you use XGEVA and for at least 5 months after your last dose. If you have questions about effective birth control, talk with your doctor.
• Lab tests, including blood calcium and mineral levels, may be performed while you use XGEVA. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• XGEVA should not be used in CHILDREN with bone growth that is not complete; XGEVA may affect bone growth and tooth development in children. Discuss any questions or concerns with your doctor.
• PREGNANCY and BREAST-FEEDING: XGEVA may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using XGEVA while you are pregnant. It is not known if XGEVA is found in breast milk. Do not breast-feed while taking XGEVA.

XGEVA side effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; constipation; decreased appetite; diarrhea; headache; joint pain; nausea; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); cough; fainting; new or unusual hip, groin, or thigh pain; severe or persistent dizziness; shortness of breath; swelling of the hands, ankles, or feet; symptoms of low blood calcium levels (eg, muscle stiffness, spasms, twitches, or cramps; burning, numbness, or tingling in your fingers, toes, or around your mouth; seizures); symptoms of low blood phosphate levels (eg, new or worsening loss of appetite, muscle weakness or pain, seizures); symptoms of jaw bone problems (eg, jaw swelling, pain, or numbness; drainage from the mouth or teeth; sores in the mouth); unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Active ingredients: denosumab

Select the most affordable brand or generic drug

Strength	Quantity	Price, USD	Country
1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]
Prolia 60 MG in 1 ML Prefilled Syringe
denosumab 120 MG in 1.7 ML Injection
denosumab 60 MG per 1 ML Prefilled Syringe

References

1. "Denosumab". https://pubchem.ncbi.nlm.nih.gov/su... (accessed August 28, 2018).
2. "Denosumab - drugbank". http://www.drugbank.ca/drugs/DB0664... (accessed August 28, 2018).

XGEVA - Frequently asked Questions

Can XGEVA be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

How should I take XGEVA?

Use XGEVA as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• XGEVA is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
• If you miss a dose of XGEVA, contact your doctor right away.

Ask your health care provider any questions you may have about how to use XGEVA.

Who should not take XGEVA?

Some medical conditions may interact with XGEVA. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are able to become pregnant
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of low blood calcium levels, high cholesterol, blood clotting problems, anemia, a bone infection, thyroid or parathyroid problems, or pancreas problems
• if you have a history of kidney problems or you are on dialysis, if you have had part of your small intestine removed, or if you have problems absorbing nutrients from food (malabsorption syndrome)
• if you cannot take daily calcium or vitamin D supplements
• if you have had or will be receiving radiation or chemotherapy
• if you have poor dental hygiene or other dental problems, or plan to have dental surgery or teeth removed
• if you have multiple myeloma (a certain type of cancer)
• if you are taking a corticosteroid (eg, prednisone)

Some MEDICINES MAY INTERACT with XGEVA. However, no specific interactions with XGEVA are known at this time.

Ask your health care provider if XGEVA may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Can XGEVA be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can XGEVA be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on XGEVA, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of XGEVA. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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The information was verified by Dr. Vishal Pawar, MD Pharmacology