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What is Seroquin

Seroquin is an antipsychotic medicine. It works by changing the actions of chemicals in the brain.
Seroquin is used to treat schizophrenia in adults and children who are at least 13 years old.
Seroquin is used to treat bipolar disorder in adults and children who are at least 10 years old.
Seroquin is also used together with antidepressant medications to treat major depressive disorder in adults.
Extended-release Seroquin (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old.
Seroquin may also be used for purposes not listed in Seroquin guide.

Seroquin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive, more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Seroquin dosing

Usual Adult Dose for Schizophrenia:

Immediate-release tablets:
Initial Dose: 25 mg orally twice a day.
The dosage may be increased in increments of 25 to 50 mg two times a day or three times a day on the second and third days. By the fourth day a dosage range of 300 mg to 400 mg daily (divided into 2 or 3 doses a day) may be achieved. Additional dosage adjustments (increases or decreases) of 25 to 50 mg twice a day may be made, as needed. However, at least 2 days should pass between the additional dosage adjustments.
Efficacy in schizophrenia has been reported with doses ranging from 150 to 750 mg/day. Maximum clinical effect has been reported at 300 mg/day. The safety of doses above 800 mg/day has not been evaluated in clinical trials.
Extended-release tablets:
Initial dose: 300 mg orally once daily without food or with a light meal.
Maintenance dose: 400 to 800 mg orally once daily depending on response and tolerance.
Maximum dose: Doses above 800 mg daily have not been studied.
The dosage of the extended-release tablets may be increased in increments of up to 300 mg daily at intervals as short as 1 day.
The efficacy of Seroquin in long-term use (over 6 weeks) has not been studied in clinical trials. Patients who respond favorably to Seroquin may be continued on the lowest dose which is effective in maintaining their remission. Patients should be periodically reassessed to determine their need for maintenance treatment.

Usual Adult Dose for Bipolar Disorder:

Immediate-release tablets:
Mania associated with bipolar I disorder as monotherapy or as adjunct therapy to lithium or divalproex:
Initial Dose: 50 mg orally twice a day
The dose may be increased to 200 mg orally twice daily on day 4 in increments of up to 50 mg twice daily. Further dosage adjustments up to 800 mg per day by day 6 should be in increments of no greater than 200 mg/day. Data has been reported to indicate that the majority of patients responded between 400 mg per day to 800 mg per day. The safety of doses above 800 mg per day has not been evaluated in clinical trials.
Immediate-release tablets:
Depressive episodes associated with bipolar disorder:
Initial dose: 50 mg orally once a day
The dose may be increased to reach 300 mg orally once a day by day 4. Some patients may require a further increase to 600 mg once a day by increasing the daily dose to 400 mg on day 5 and 600 mg on day 8 of treatment. Efficacy was demonstrated in this patient population at both 300 mg and 600 mg per day. However, no additional benefit was observed in patients receiving 600 mg per day as compared to those patients receiving 300 mg per day.
Extended-release tablets:
Bipolar Depression:
(Depressive Episodes Associated with Bipolar Disorder)
Usual dose for Acute Treatment: administer orally once daily in the evening starting with 50 mg per day and increasing doses to reach 300 mg per day by day 4.
Recommended Dosing Schedule: Day 1 - 50 mg, Day 2 - 100, mg, Day 3 - 200 mg, & Day 4 - 300 mg
Bipolar Mania:
Usual dose for Acute Monotherapy or Adjunct Therapy (with lithium or divalproex): administer orally once daily in the evening starting with 300 mg on day 1, 600 mg on day 2, and adjust between 400 mg and 800 mg per day thereafter depending on the clinical response and tolerance of the individual patient.
Bipolar Maintenance:
Continue treatment at the dosage required to maintain symptom remission.
While there is no body of evidence available to specifically address how long patients should remain on Seroquin extended-release tablets, maintenance of efficacy in Bipolar I Disorder has been demonstrated with Seroquin (administered orally twice daily totaling 400 to 800 mg per day) as adjunct therapy to lithium or divalproex. Generally, in the maintenance phase, patients continued on the same dose on which they were stabilized during the stabilization phase. Patients should be periodically reassessed to determine the need for maintenance treatment and the appropriate dose for such treatment.

Usual Adult Dose for Depression:

As adjunctive therapy to antidepressants for use in the treatment of major depressive disorder:
Extended-release tablets:
Initial dose: 50 mg orally once daily in the evening
On day 3, the dose can be increased to 150 mg once daily in the evening.
Range: 150 mg to 300 mg orally daily. Doses above 300 mg have not been studied.

Usual Geriatric Dose for Schizophrenia:

Immediate-release tablets:
Initial Dose: 25 mg orally once a day.
The dose may be increased daily in increments of 25 mg/day to 50 mg/day to an effective dose, depending on the clinical response and tolerability of the patient.
Efficacy in schizophrenia has been reported with doses ranging from 150 to 750 mg/day. Maximum clinical effect has been reported at 300 mg/day. The safety of doses above 800 mg/day has not been evaluated in clinical trials.
Extended-release tablets:
When an effective immediate-release dose has been reached, the patient may be switched to the extended-release formulation at an equivalent dose.
The efficacy of Seroquin in long-term use (over 6 weeks) has not been studied in clinical trials. Patients who respond favorably to Seroquin may be continued on the lowest dose which is effective in maintaining their remission. Patients should be periodically reassessed to determine their need for maintenance treatment.

Usual Geriatric Dose for Bipolar Disorder:

Extended-release tablets:
Initial dose: 50 mg/day
The dose can be increased in increments of 50 mg/day depending on the response and tolerance of the individual patient.

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Cipla Limited (Protec)
25 mg10 Tablet$0.29India


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References

  1. Dailymed."Quetiapine fumarate: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Quetiapine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "Quetiapine". http://www.drugbank.ca/drugs/DB0122... (accessed August 28, 2018).

Seroquin - Frequently asked Questions

Can Seroquin be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

Who should not take Seroquin?

You should not use Seroquin if you are allergic to it.

Seroquin is not approved for use in psychotic conditions related to dementia. Seroquin may increase the risk of death in older adults with dementia-related conditions.

To make sure Seroquin is safe for you, tell your doctor if you have:

Some young people have thoughts about suicide when first taking Seroquin. Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

FDA pregnancy category C. It is not known whether Seroquin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Seroquin, do not stop taking it without your doctor's advice.

Seroquin can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Seroquin.

Do not give Seroquin to a child without a doctor's advice. Extended-release Seroquin (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old.

What other drugs will affect Seroquin?

Taking Seroquin with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking Seroquin with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with Seroquin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Seroquin, especially:

This list is not complete and many other drugs can interact with Seroquin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

How should I take Seroquin?

Follow all directions on your prescription label. Never take Seroquin in larger amounts, or for longer than recommended by your doctor. High doses or long-term use of Seroquin can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements.

Take this medicine with a full glass of water. You may take Seroquin with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Seroquin may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking Seroquin.

You should not stop using Seroquin suddenly. Stopping suddenly may make your condition worse.

Blood pressure may need to be checked often in a child or teenager taking Seroquin.

This medication can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking Seroquin.

Store at room temperature away from moisture and heat.

Can Seroquin be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Seroquin be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on Seroquin, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Seroquin. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

Patient reports

Patient reported useful

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Patient reported side effects

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Patient reported price estimates

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One patient reported doses

What is the specific doses you have used?
Seroquin May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient's condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.
Patients%
11-50mg1
100.0%


Patient reported time for results

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The information was verified by Dr. Vishal Pawar, MD Pharmacology