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Instrel |
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What is Instrel
Instrel is in the group of medicines called bisphosphonates. It alters the cycle of bone formation and breakdown in the body. Instrel slows bone Instrel while increasing bone mass, which may prevent bone fractures.Instrel is used in men and women to treat or prevent osteoporosis that is caused by menopause or by taking steroids. Instrel is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.
Instrel may also be used for purposes not listed in Instrel guide.
Instrel side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Stop using Instrel and call your doctor at once if you have:
- chest pain, new or worsening heartburn;
- difficulty or pain when swallowing;
- pain or burning under the ribs or in the back;
- severe heartburn, burning pain in your upper stomach, or coughing up blood;
- new or worsening heartburn;
- severe joint, bone, or muscle pain, new or unusual pain in your thigh or hip;
- fever, body aches, flu symptoms; or
- jaw pain, numbness, or swelling.
- new or unusual pain in your thigh or hip;
Common side effects may include:
- mild heartburn, bloating;
- mild nausea, vomiting, or stomach pain;
- diarrhea, gas, or constipation;
- mild joint pain or swelling;
- swelling in your hands or feet; or
- dizziness, eye pain, headache.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects
Instrel dosing
Usual Adult Dose for Osteoporosis:
70 mg orally once weekly or 10 mg orally once daily.For glucocorticoid-induced osteoporosis: 5 mg once daily or 10 mg once daily for postmenopausal women not receiving estrogen.
Usual Adult Dose for Paget's Disease:
40 mg orally once a day.Therapy for Paget's disease should continue for 6 months and may need to be repeated for another 6 months if relapse occurs.
Usual Adult Dose for Prevention of Osteoporosis:
5 mg orally once daily or 35 mg orally once weekly.Select the most affordable brand or generic drug
References
- Dailymed."Alendronate sodium: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "Alendronic acid". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "Alendronic acid". http://www.drugbank.ca/drugs/DB0063... (accessed August 28, 2018).
Instrel - Frequently asked Questions
Can Instrel be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
How should I take Instrel?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Instrel tablets are taken either once each day or once each week.
To use the Instrel effervescent tablet, dissolve the tablet in at least 4 ounces of water. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.
Take the Instrel tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take an Instrel tablet only once a week, take it on the same day each week and always first thing in the morning.
Take Instrel with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking the tablet.
Do not crush, chew, or suck the Instrel tablet. Swallow the pill whole.
After taking Instrel, carefully follow these instructions:
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Do not lie down or recline for at least 30 minutes after taking Instrel.
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Do not eat or drink anything other than plain water.
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Do not take any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking Instrel. It may be best to take your other medicines at a different time of the day. Talk with your doctor about the best dosing schedule for your other medicines.
To be sure this medication is helping your condition, your bone mineral density will need to be tested on a regular basis. You may not need to take Instrel for longer than 3 to 5 years if you take it for osteoporosis. Visit your doctor regularly.
If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Instrel. You may need to stop using the medicine for a short time.
Instrel is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication, and exercise routines very closely.
Store at room temperature away from moisture and heat.
Who should not take Instrel?
You should not take Instrel if you are allergic to it, or if you have low levels of calcium in your blood, or a problem with the movement of muscles in your esophagus.
Do not take an Instrel tablet if you cannot sit upright or stand for at least 30 minutes. Instrel can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking this medication.
To make sure Instrel is safe for you, tell your doctor if you have:
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trouble swallowing;
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a vitamin D deficiency;
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a dental problem;
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kidney disease; or
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an ulcer or other problem in your stomach or esophagus.
In rare cases, this medicine may cause bone Instrel (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Instrel, the more likely you are to develop this condition.
Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.
Talk with your doctor about the risks and benefits of using this medication.
FDA pregnancy category C. It is not known whether Instrel will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether Instrel passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
What other drugs will affect Instrel?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Instrel, especially:
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NSAIDs (non-steroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with Instrel, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Can Instrel be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Instrel be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
Reviews
Following the study conducted by gmedication.com on Instrel, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Instrel. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.Patient reports
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The information was verified by Dr. Vishal Pawar, MD Pharmacology