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What is Doriman

Doriman is an antibiotic in a group of drugs called fluoroquinolones. Doriman fights bacteria in the body.
Doriman is used to treat different types of bacterial infections. Doriman is also used to treat people who have been exposed to anthrax.
Doriman may also be used for purposes not listed in Doriman guide.

How is Doriman given?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Doriman is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Doriman must be injected slowly, over at least 60 minutes.
Drink plenty of liquids while you are using Doriman.
Doriman is usually given every 8 to 12 hours for up to 14 days. Some infections may need to be treated for 4 to 6 weeks. Anthrax exposure is usually treated for 60 days.
Follow your doctor's dosing instructions very carefully.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Doriman will not treat a viral infection such as the flu or a common cold.
If you use this medicine long-term, you may need frequent medical tests at your doctor's office.
Store at room temperature away from moisture, heat, and light. Do not freeze.
Do not use Doriman if it has changed colors or has particles in it. Call your pharmacist for new medication.

Doriman side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives, tingling; fast or slow heartbeats, weak pulse, feeling like you might pass out; difficult breathing; swelling of your face, lips, tongue, or throat.
Doriman may cause swelling or tearing of (rupture) a tendon. Doriman can also have serious effects on your nerves, and may cause permanent nerve damage. Stop using this medicine and call your doctor at once if you have:

Also, stop using Doriman and call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Doriman dosing

Usual Adult Dose for Anthrax Prophylaxis:

Prophylaxis postexposure to inhalational Bacillus anthracis:
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Treatment should start as soon as possible following suspected or confirmed exposure. Total duration of therapy is 60 days.

Usual Adult Dose for Inhalation Bacillus anthracis:

(Not approved by FDA)
Centers for Disease Control and Prevention (CDC) recommendations:
Treatment of inhalational anthrax associated with bioterrorism attack: 400 mg IV every 12 hours plus 1 or 2 additional antibiotics with activity against the causative organism; these drugs may include rifampin, vancomycin, penicillin, ampicillin, chloramphenicol, imipenem, clindamycin, and clarithromycin
Duration: The switch from IV to oral antimicrobial therapy (ciprofloxacin 500 mg orally every 12 hours) may be made as soon as is clinically feasible. Therapy should continue for a total of 60 days (IV and oral combined).

Usual Adult Dose for Cutaneous Bacillus anthracis:

CDC recommendations:
Treatment of cutaneous anthrax associated with bioterrorism attack: 500 mg orally every 12 hours for 60 days
IV therapy (ciprofloxacin 400 mg IV every 12 hours) with multiple drugs is recommended if there is evidence of systemic involvement, severe edema, or if head or neck lesions are present.

Usual Adult Dose for Bacteremia:

Secondary bacteremia associated with urinary tract infections caused by Escherichia coli: 400 mg IV every 12 hours
Therapy should be continued for 7 to 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Bronchitis:

Acute exacerbations of chronic bronchitis:
Mild/moderate:
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Severe/complicated:
IV: 400 mg IV every 8 hours
Oral: 750 mg orally every 12 hours
Duration: 7 to 14 days

Usual Adult Dose for Chancroid:

CDC recommendations: 500 mg orally twice a day for 3 days
The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Cholera:

(Not approved by FDA)
Infectious Diseases Society of America (IDSA) recommendations: 1 g orally once, as an adjunct to fluid and electrolyte replacement

Usual Adult Dose for Cystitis:

Acute uncomplicated:
Immediate-release: 250 mg orally every 12 hours
Extended-release: 500 mg orally every 24 hours
Duration: 3 days

Usual Adult Dose for Febrile Neutropenia:

Empirical therapy in febrile neutropenic patients:
Severe: 400 mg IV every 8 hours for 7 to 14 days, in combination with piperacillin 50 mg/kg IV every 4 hours

Usual Adult Dose for Gonococcal Infection -- Uncomplicated:

Uncomplicated urethral and cervical gonococcal infections: 250 mg orally one time
Due to high rates of resistance, the CDC does not recommend fluoroquinolones for treatment of gonococcal infections in the United States. Ceftriaxone or oral cefixime is recommended as first-line treatment of gonorrhea in the United States. Antimicrobial susceptibility patterns should be monitored.
Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.
The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Granuloma Inguinale:

CDC recommendations: 750 mg orally twice a day for at least 3 weeks and until all lesions have completely healed
Doriman is recommended as an alternate regimen by the CDC. Doxycycline is considered the drug of choice.
The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Infection Prophylaxis:

(Not approved by FDA)
Patients with neutropenia: 500 mg orally every 12 hours; alternatively, 400 mg IV every 12 hours may be given for particularly ill patients
The duration of therapy may vary with the duration of the patient's neutropenia.

Usual Adult Dose for Infectious Diarrhea:

Mild/moderate/severe: 500 mg orally every 12 hours for 5 to 7 days
IDSA recommendations:
E coli species, Aeromonas, Plesiomonas: 500 mg orally twice a day for 3 days

Usual Adult Dose for Diverticulitis:

Complicated intraabdominal infection (used in combination with metronidazole):
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Duration: 7 to 14 days

Usual Adult Dose for Intraabdominal Infection:

Complicated intraabdominal infection :
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Duration: 7 to 14 days

Usual Adult Dose for Peritonitis:

Complicated intraabdominal infection (used in combination with metronidazole):
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Duration: 7 to 14 days

Usual Adult Dose for Joint Infection:

Mild/moderate:
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Severe/complicated:
IV: 400 mg IV every 8 hours
Oral: 750 mg orally every 12 hours
Duration: at least 4 to 6 weeks

Usual Adult Dose for Osteomyelitis:

Mild/moderate:
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Severe/complicated:
IV: 400 mg IV every 8 hours
Oral: 750 mg orally every 12 hours
Duration: at least 4 to 6 weeks

Usual Adult Dose for Meningococcal Meningitis Prophylaxis:

CDC recommendations: 500 mg orally once

Usual Adult Dose for Mycobacterium avium-intracellulare -- Treatment:

(Not approved by FDA)
400 mg IV or 750 mg orally every 12 hours, in combination with at least 3 other antimycobacterial drugs (e.g., clarithromycin or azithromycin, ethambutol, rifabutin, amikacin)

Usual Adult Dose for Nosocomial Pneumonia:

Mild/moderate/severe: 400 mg IV every 8 hours for 10 to 14 days
Initial empiric treatment with broad-spectrum coverage according to the hospital's and/or ICU's antibiogram is recommended if multidrug-resistant organisms are suspected.

Usual Adult Dose for Plague:

Treatment of plague used as a biological weapon:
Treatment, contained-casualty setting: 400 mg IV every 12 hours for 10 days; may switch to oral Doriman 500 mg twice a day when clinically indicated
The Working Group on Civilian Biodefense has recommended Doriman as an alternative to streptomycin and gentamicin if they are contraindicated, unavailable, or inactive in vitro.
Treatment, mass-casualty setting: 500 mg orally twice a day for 10 days
Postexposure prophylaxis: 500 mg orally twice a day for 7 days
The Working Group on Civilian Biodefense has recommended Doriman or doxycycline for plague treatment in a mass casualty setting and for postexposure prophylaxis.

Usual Adult Dose for Pneumonia:

Lower respiratory tract infection:
Mild/moderate:
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Severe/complicated:
IV: 400 mg IV every 8 hours
Oral: 750 mg orally every 12 hours
Duration: 7 to 14 days
Doriman is not considered the drug of choice for the treatment of presumed or confirmed pneumonia secondary to Streptococcus pneumoniae.

Usual Adult Dose for Prostatitis:

Chronic bacterial prostatitis :
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Duration: 28 days

Usual Adult Dose for Pyelonephritis:

Acute uncomplicated:
Cipro(R) XR: 1000 mg orally every 24 hours for 7 to 14 days

Usual Adult Dose for Salmonella Gastroenteritis:

IDSA recommendations:
Non-typhi species of Salmonella: 500 mg orally twice a day for 5 to 7 days
Up to 14 days (or longer if relapsing) of treatment may be required for immunocompromised patients.

Usual Adult Dose for Shigellosis:

Mild/moderate/severe infectious diarrhea: 500 mg orally every 12 hours for 5 to 7 days
IDSA recommendations: 500 mg orally twice a day for 3 days
Up to 7 to 10 days of treatment may be required for immunocompromised patients.
A single 1 gram dose may be effective for non-dysentery shigellosis.

Usual Adult Dose for Sinusitis:

Mild/moderate:
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Duration: 10 days

Usual Adult Dose for Skin or Soft Tissue Infection:

Mild/moderate:
IV: 400 mg IV every 12 hours
Oral: 500 mg orally every 12 hours
Severe/complicated:
IV: 400 mg IV every 8 hours
Oral: 750 mg orally every 12 hours
Duration: 7 to 14 days
Vibrio vulnificus: 400 mg IV every 12 hours plus ceftazidime 1 to 2 g IV every 8 hours or cefotaxime 2 g IV every 8 hours

Usual Adult Dose for Traveler's Diarrhea:

500 mg orally every 12 hours
Therapy should be continued for about 5 to 7 days in severely ill patients. Most cases are self-limited, and prudent withholding of antibiotics in mild cases does not appear to slow recovery in most patients. However, immunocompromised patients may require longer courses of therapy.

Usual Adult Dose for Tuberculosis -- Active:

(Not approved by FDA)
750 mg orally or 400 mg IV every 12 hours
May be given in combination with at least 3 other active drugs for treatment of multi-drug resistant TB, or when the patient is intolerant of first-line agents. AFB smear and culture should be monitored monthly.
Duration: Treatment for TB should generally continue for 18 to 24 months, or for 12 to 18 months after culture results are negative.

Usual Adult Dose for Tularemia:

Use of tularemia as a biological weapon:
Treatment, contained casualty setting: 400 mg IV twice a day for 10 days; may switch to oral Doriman 500 mg twice a day when clinically indicated
The Working Group on Civilian Biodefense has recommended Doriman as an alternative to streptomycin and gentamicin if they are contraindicated, not available, or inactive in vitro.
Treatment, mass casualty setting and postexposure prophylaxis: 500 mg orally twice a day for 14 days
The Working Group on Civilian Biodefense has recommended Doriman or doxycycline for tularemia treatment in a mass casualty setting and for postexposure prophylaxis.

Usual Adult Dose for Salmonella Enteric Fever:

Mild/moderate: 500 mg orally every 12 hours for 10 days

Usual Adult Dose for Typhoid Fever:

Mild/moderate: 500 mg orally every 12 hours for 10 days

Usual Adult Dose for Urinary Tract Infection:

Acute uncomplicated :
Immediate-release: 250 mg orally every 12 hours
Extended-release: 500 mg orally every 24 hours
Duration: 3 days
Mild/moderate:
IV: 200 mg IV every 12 hours
Immediate-release: 250 mg orally every 12 hours
Duration: 7 to 14 days
Severe/complicated:
IV: 400 mg IV every 12 hours (or every 8 hours)
Immediate-release: 500 mg orally every 12 hours
Cipro(R) XR: 1000 mg orally every 24 hours
Duration: 7 to 14 days

Usual Pediatric Dose for Anthrax Prophylaxis:

Prophylaxis postexposure to inhalational Bacillus anthracis:
IV: 10 mg/kg IV every 12 hours (maximum dose: 400 mg/dose)
Oral: 15 mg/kg orally every 12 hours (maximum dose: 500 mg/dose)
Treatment should start as soon as possible following suspected or confirmed exposure. Total duration of therapy (IV and oral combined) is 60 days.

Usual Pediatric Dose for Urinary Tract Infection:

Complicated infection due to E coli:
1 to 18 years:
IV: 6 to 10 mg/kg IV every 8 hours
Oral: 10 to 20 mg/kg orally every 12 hours (maximum dose: 750 mg/dose)
Total duration of therapy (IV and oral combined) is 10 to 21 days.
Doriman is not a drug of first choice due to a higher rate of adverse reactions in this population.

Usual Pediatric Dose for Pyelonephritis:

Due to E coli:
1 to 18 years:
IV: 6 to 10 mg/kg IV every 8 hours (maximum dose: 400 mg/dose)
Oral: 10 to 20 mg/kg orally every 12 hours (maximum dose: 750 mg/dose)
Total duration of therapy (IV and oral combined) is 10 to 21 days.
Doriman is not a drug of first choice due to a higher rate of adverse reactions in this population.

Usual Pediatric Dose for Inhalation Bacillus anthracis:

CDC recommendations:
Treatment of inhalational anthrax associated with bioterrorism attack:
Children: 10 to 15 mg/kg IV every 12 hours (not to exceed 1 g/day) plus 1 or 2 additional antibiotics with activity against the causative organism; these drugs may include rifampin, vancomycin, penicillin, ampicillin, chloramphenicol, imipenem, clindamycin, and clarithromycin
Duration: The switch from IV to oral antimicrobial therapy [ciprofloxacin 10 to 15 mg/kg orally every 12 hours (not to exceed 1 g/day)] should occur as soon as is clinically feasible. Therapy should continue for a total of 60 days (IV and oral combined).

Usual Pediatric Dose for Cutaneous Bacillus anthracis:

(Not approved by FDA)
CDC recommendations:
Treatment of cutaneous anthrax associated with bioterrorism attack:
Children: 10 to 15 mg/kg orally every 12 hours (not to exceed 1 g/day) for 60 days
IV therapy [ciprofloxacin 10 to 15 mg/kg IV every 12 hours (not to exceed 1 g/day)] with multiple drugs is recommended if there is evidence of systemic involvement, severe edema, or if head or neck lesions are present.

Usual Pediatric Dose for Pneumonia with Cystic Fibrosis:

Study (n=67)
5 years or older: 10 mg/kg IV every 8 hours for 1 week followed by 20 mg/kg orally every 12 hours
Total duration of therapy: 10 to 21 days

Usual Pediatric Dose for Plague:

(Not approved by FDA)
Use of plague as a biological weapon:
Treatment, contained-casualty setting: 15 mg/kg IV twice a day for 10 days (maximum dose: 1 g/day); may switch to oral Doriman when clinically indicated
The Working Group on Civilian Biodefense has recommended Doriman as an alternative to streptomycin and gentamicin if they are contraindicated, unavailable, or inactive in vitro.
Treatment, mass casualty setting: 20 mg/kg orally twice a day for 10 days (maximum dose: 1 g/day)
Postexposure prophylaxis: 20 mg/kg orally twice a day for 7 days (maximum dose: 1 g/day)
The Working Group on Civilian Biodefense has recommended Doriman or doxycycline for plague treatment in a mass casualty setting and for postexposure prophylaxis.

Usual Pediatric Dose for Tularemia:

Use of tularemia as a biological weapon:
Treatment, contained casualty setting: 15 mg/kg IV twice a day (maximum dose: 1 g/day) for 10 days; may switch to oral Doriman when clinically indicated
The Working Group on Civilian Biodefense has recommended Doriman as an alternative to streptomycin and gentamicin if they are contraindicated, not available, or inactive in vitro.
Treatment, mass casualty setting and postexposure prophylaxis: 15 mg/kg orally twice a day (maximum dose: 1 g/day) for 14 days
The Working Group on Civilian Biodefense has recommended doxycycline or Doriman for tularemia treatment in a mass casualty setting and for postexposure prophylaxis.

Select the most affordable brand or generic drug


StrengthQuantityPrice, USDCountry
Cipiquin 250 mg Tablet $0.05
250 mg x 10's $0.49
CIPIQUIN tab 250 mg x 10's $0.49Agio
Cipiquin 250mg TAB / 10 $0.49
Cipiquin 500 mg Tablet $0.09
500 mg x 10's $0.91
CIPIQUIN tab 500 mg x 10's $0.91Agio
Cipiquin 500mg TAB / 10 $0.91
10 %100 milliliters$84.00Australia, Canada, NZ, Singapore, UK
Ciprolar 750mg Suspension $0.24Lark Laboratories Ltd
CIPROLAR Capsule/ Tablet / 250mg (10 units) $0.35Lark Laboratories
125 mg x 5 mL x 50ml $0.49
CIPROLAR tab 500 mg x 10's $0.59Lark
Ciprolar 750 mg Tablet $0.09
Ciprotop 500 mg Tablet $0.08
Cirok 500 mg x 100's $70.00
Cirok film-coated tab 500 mg 100's $70.00One Pharma
Cirok 200 mg/100 mL x 1's $17.90
Cirok infusion 200 mg/100 mL 1's $17.90One Pharma
1 gm10 $1.11
Coflox 500mg TAB / 10 $0.56
COFLOX 750MG TABLET 1 strip(s) (10 tablets each) $0.83Macleods Pharmaceuticals Pvt Ltd
750 mg x 10's $1.11
COFLOX tab 750 mg x 10's $1.11Macleods
Hicip 250 mg Tablet $0.05
250 mg x 10's $0.49
Hicip 250mg TAB / 10 $0.49
HICIP Capsule/ Tablet / 250mg (10 units) $0.49Intra Labs
Hicip 500 mg Tablet $0.08
500 mg x 10's $0.76
Hicip 500mg TAB / 10 $0.76
HICIP Capsule/ Tablet / 500mg (10 units) $0.76Intra Labs
Hyprocel 500 mg x 100's $62.80
Interflox 500 mg x 12's $8.17
Interflox 250 mg x 30's $11.10
250 mg x 10's $0.49
POWERCIP tab 250 mg x 10's $0.49Invision (Infalife)
Powercip 250mg 10 / TAB $0.49
500 mg50 $534.00
250 mg10 $0.36
QUINCIP Capsule/ Tablet / 250mg (10 units) $0.36Baroque Pharmaceuticals
QUINCIP Capsule/ Tablet / 500mg (10 units) $0.68Baroque Pharmaceuticals
QUINCIP Capsule/ Tablet / 750mg (10 units) $1.05Baroque Pharmaceuticals
Sutid 500 mg x 50's $40.00
Ultraflox 250 mg Tablet $0.04
Ultraflox 200 mg Ultratech Pharma Tablet $0.06
Ultraflox 500mg TAB / 10 $0.95

References

  1. Dailymed."Ciprofloxacin; dexamethasone: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Ciprofloxacin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "Ciprofloxacin". http://www.drugbank.ca/drugs/DB0053... (accessed August 28, 2018).

Doriman - Frequently asked Questions

Can Doriman be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

Who should not take Doriman?

You should not use Doriman if you are allergic to it, or if:

You may not be able to use Doriman if you have a muscle disorder. Tell your doctor if you have a history of myasthenia gravis.

To make sure Doriman is safe for you, tell your doctor if you have:

Doriman may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This can happen during treatment or up to several months after you stop using Doriman. Tendon problems may be more likely to occur if you are over 60, if you use steroid medication, or if you have had a kidney, heart, or lung transplant.

FDA pregnancy category C. It is not known whether Doriman will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

Doriman can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medicine to anyone under 18 years old without medical advice.

How should I take Doriman?

You should not use this medicine if you are also taking tizanidine.

You may not be able to use Doriman if you have a muscle disorder. Tell your doctor if you have a history of myasthenia gravis.

Doriman may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This effect may be more likely to occur if you are over 60, if you use steroid medication, or if you have had a kidney, heart, or lung transplant.

Call your doctor at once if you have sudden pain, swelling, bruising, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.

What other drugs will affect Doriman?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Doriman, especially:

This list is not complete. Other drugs may interact with Doriman, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Can Doriman be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Doriman be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on Doriman, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Doriman. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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The information was verified by Dr. Vishal Pawar, MD Pharmacology