Alfamydex

Name: Alfamydex Price Comparison: Uses, Dosage, Form & Side Effects
Creator: gmedication.com
Published: 2021-11-01T10:10:10+00:00

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What is Dexamethasone (Alfamydex)
How is Dexamethasone injection given?
What should I avoid after receiving Dexamethasone?
Dexamethasone (Alfamydex) side effects
Dexamethasone (Alfamydex) dosing
What is Gentamicin (Alfamydex)
Gentamicin (Alfamydex) side effects
Gentamicin (Alfamydex) dosing

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Frequently asked Questions

How should I take Gentamicin (Alfamydex)?
How should I take Dexamethasone (Alfamydex)?
What other drugs will affect Gentamicin (Alfamydex)?
Who should not take Dexamethasone (Alfamydex)?
What other drugs will affect Dexamethasone (Alfamydex)?
Who should not take Gentamicin (Alfamydex)?

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consists of Dexamethasone, Gentamicin.

Dexamethasone (Alfamydex)

What is Dexamethasone (Alfamydex)

Dexamethasone (Alfamydex) is a steroid that prevents the release of substances in the body that cause inflammation.
Dexamethasone (Alfamydex) is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, breathing disorders, inflammatory eye conditions, blood cell disorders, leukemia, or endocrine disorders.
Dexamethasone (Alfamydex) may also be used for purposes not listed in Dexamethasone (Alfamydex) guide.

How is Dexamethasone injection given?

Dexamethasone (Alfamydex) is often injected into a muscle or into a vein through an IV. A healthcare provider will give you this injection. Dexamethasone (Alfamydex) injection is usually given for only a few days.
Your dosage needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.
Dexamethasone (Alfamydex) can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Dexamethasone (Alfamydex).
After your treatment ends, you may have withdrawal symptoms such as fever, weakness, and joint or muscle pain. You should not stop using Dexamethasone (Alfamydex) suddenly.

What should I avoid after receiving Dexamethasone?

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using a steroid.
Do not receive a "live" vaccine while using Dexamethasone (Alfamydex). Steroids may increase your risk of harmful effects from a live vaccine. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Dexamethasone (Alfamydex) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have:

problems with your vision;
swelling, rapid weight gain, feeling short of breath;
severe depression, unusual thoughts or behavior, seizure (convulsions);
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Common side effects may include:

sleep problems (insomnia), mood changes;
acne, dry skin, thinning skin, bruising or discoloration;
slow wound healing;
increased sweating;
headache, dizziness, spinning sensation;
bloating; or
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Dexamethasone (Alfamydex) dosing

Usual Adult Dose for Acute Mountain Sickness:

Oral, IV and IM :
0.75 to 9 mg per day in divided doses every 6 to 12 hours
IM (as acetate):
8 to 16 mg, may repeat in 1 to 3 weeks
Intralesional (as acetate):
0.8 to 1.6 mg
Intraarticular and soft tissue as acetate):
4 to 16 mg, may repeat in 1 to 3 weeks
Intraarticular, intralesional, or soft tissue (as sodium phosphate):
0.4 to 6 mg per day

Usual Adult Dose for Asthma -- Acute:

Oral, IV and IM (injections as sodium phosphate):
0.75 to 9 mg per day in divided doses every 6 to 12 hours
IM (as acetate):
8 to 16 mg, may repeat in 1 to 3 weeks
Intralesional (as acetate):
0.8 to 1.6 mg
Intraarticular and soft tissue as acetate):
4 to 16 mg, may repeat in 1 to 3 weeks
Intraarticular, intralesional, or soft tissue (as sodium phosphate):
0.4 to 6 mg per day

Usual Adult Dose for Croup:

Usual Adult Dose for Anti-inflammatory:

Usual Adult Dose for Cerebral Edema:

Initial 10 mg IV once, followed by 4 mg IM every 6 hours until symptoms of cerebral edema subside. Dosage may be reduced after 2 to 4 days, and discontinued slowly over a period of 5 to 7 days.

Usual Adult Dose for Cushing's Syndrome:

Suppression test or diagnosis for Cushing's syndrome:
1 mg orally at 11 p.m. Blood plasma cortisol measurement at 8 a.m. the next morning.
or
0.5 mg by mouth every 6 hours for 48 hours.
Differentiation of Cushing's syndrome due to ACTH excess from Cushing's due to other causes: Oral: Dexamethasone (Alfamydex) 2 mg every 6 hours for 48 hours (with 24 hour urine collection for 17 hydroxycorticosteroid excretion).

Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:

Prophylaxis:
10 mg to 20 mg orally or IV, 15 to 30 minutes before treatment on each treatment day
For continuous infusion of chemotherapy:
10 mg orally or IV every 12 hours on each treatment day.
For mildly emetogenic therapy: 4 mg oral, IV or IM every 4 to 6 hours.
Delayed nausea and vomiting:
8 mg orally every 12 hours for 2 days; then 4 mg every 12 hours for 2 days.
or
20 mg orally 1 hour before chemotherapy; then 10 mg orally 12 hours after chemotherapy; then 8 mg orally every 12 hours for 4 doses; then 4 mg orally every 12 hours for 4 doses.

Usual Adult Dose for Shock:

Addisonian crisis/shock:
4 to 10 mg IV as single dose, repeat if necessary.
Unresponsive shock:
1 to 6 mg/kg IV as a single dose or up to 40 mg initially followed by repeat doses every 2 to 6 hours while shock persists.

Usual Adult Dose for Multiple Myeloma:

Multiple myeloma: Oral, IV: 40 mg/day, days 1 to 4, 9 to 12, and 17 to 20, repeated every 4 weeks.

Usual Adult Dose for Multiple Sclerosis:

Multiple sclerosis (acute exacerbation): Oral: 30 mg/day for 1 week, followed by 4 to 12 mg/day for 1 month.

Usual Adult Dose for Adrenal Insufficiency:

Physiological replacement: Oral, IM, IV : 0.03 to 0.15 mg/kg/day or 0.6 to 0.75 mg/m2/day in divided doses every 6 to 12 hours.

Usual Pediatric Dose for Cerebral Edema:

Initial loading dose: 1 to 2 mg/kg once orally, IV or IM.
Maintenance: 1 to 1.5 mg /kg/day, give in divided doses every 4 to 6 hours for 5 days then taper for 5 days, then discontinue. Maximum dose: 16 mg/day.

Usual Pediatric Dose for Meningitis -- Meningococcal:

:
Meningitis (H. influenzae type b): Infants and Children 6 weeks or older: IV: 0.15 mg/kg/dose every 6 hours for the first 2 to 4 days of antibiotic treatment; start Dexamethasone (Alfamydex) 10 to 20 minutes before or with the first dose of antibiotic. If antibiotics have already been administered, Dexamethasone (Alfamydex) use has not been shown to improve patient outcome and is not recommended. Note: For pneumococcal meningitis, data has not shown clear benefit from Dexamethasone (Alfamydex) administration; risk and benefits should be considered prior to use.

Usual Pediatric Dose for Meningitis -- Haemophilus influenzae:

(Not approved by FDA):
Meningitis (H. influenzae type b): Infants and Children 6 weeks or older: IV: 0.15 mg/kg/dose every 6 hours for the first 2 to 4 days of antibiotic treatment; start Dexamethasone (Alfamydex) 10 to 20 minutes before or with the first dose of antibiotic. If antibiotics have already been administered, Dexamethasone (Alfamydex) use has not been shown to improve patient outcome and is not recommended. Note: For pneumococcal meningitis, data has not shown clear benefit from Dexamethasone (Alfamydex) administration; risk and benefits should be considered prior to use.

Usual Pediatric Dose for Meningitis -- Pneumococcal:

Usual Pediatric Dose for Meningitis - Listeriosis:

Usual Pediatric Dose for Anti-inflammatory:

0.08 to 0.3 mg/kg/day or 2.5 to 5 mg/m2/day in divided doses every 6 to 12 hours.

Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced:

:
Prior to chemotherapy:
10 mg/meter squared IV for first dose (maximum 20 mg) then 5 mg/meter squared/dose every 6 hours as needed.

Usual Pediatric Dose for Asthma -- Acute:

Asthma exacerbation: Oral, IM, IV: 0.6 mg/kg once (maximum dose: 16 mg)

Usual Pediatric Dose for Croup:

:
Croup (laryngotracheobronchitis): Oral, IM, IV: 0.6 mg/kg once (maximum: 20 mg). A single dose of 0.15 mg/kg has also been shown effective.

Usual Pediatric Dose for Adrenal Insufficiency:

Physiological replacement: Oral, IM, IV (should be given as sodium phosphate): 0.03 to 0.15 mg/kg/day or 0.6 to 0.75 mg/m2/day in divided doses every 6 to 12 hours.

Usual Pediatric Dose for Acute Mountain Sickness:

:
Acute mountain sickness (AMS)/high altitude cerebral edema (HACE); treatment: Oral, IM, IV: 0.15 mg/kg/dose every 6 hours; consider using for high altitude pulmonary edema because of associated HACE with this condition.

Usual Pediatric Dose for Bronchopulmonary Dysplasia:

(Not approved by FDA):
Bronchopulmonary dysplasia, facilitation of ventilator wean: postnatal age =7 days: Oral, IV: Initial: 0.15 mg/kg/day given in divided doses every 12 hours for 3 days, then tapered every 3 days over 7 days; total Dexamethasone (Alfamydex) dose: 0.89 mg/kg given over 10 days; others have used 0.2 mg/kg/day given once daily and tapered every 3 days over 7 days (total Dexamethasone (Alfamydex) dose: 1 mg/kg) ( or tapered over 14 days (total Dexamethasone (Alfamydex) dose: 1.9 mg/kg). Note: High doses (0.5 mg/kg/day) do not confer additional benefit over lower doses, are associated with higher incidence of adverse effects (including adverse neurodevelopmental outcomes), and are not recommended for use. However, a meta-analysis reported total cumulative doses greater than 4 mg/kg reduced the relative risk for the combined outcome, mortality, or bronchopulmonary dysplasia; further studies are needed.

Gentamicin (Alfamydex)

What is Gentamicin (Alfamydex)

Gentamicin (Alfamydex) is an antibiotic. It fights bacteria in the body.
Gentamicin (Alfamydex) is used to treat severe or serious bacterial infections.
Gentamicin (Alfamydex) may also be used for purposes other than those listed in Gentamicin (Alfamydex) guide.

Gentamicin (Alfamydex) side effects

If you experience any of the following serious side effects, stop taking Gentamicin (Alfamydex) and seek emergency medical attention:

an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);
little or no urine;
decreased hearing or ringing in the ears;
dizziness, clumsiness, or unsteadiness;
numbness, skin tingling, muscle twitching, or seizures; or
severe watery diarrhea and abdominal cramps.

Other, less serious side effects may be more likely to occur. Continue to take Gentamicin (Alfamydex) and talk to your doctor if you experience

increased thirst;
loss of appetite;
nausea or vomiting;
a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Gentamicin (Alfamydex) dosing

Usual Adult Dose for Bacteremia:

1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: 14 days, depending on the site, nature, and severity of the bacteremia
Comments: Limiting the duration of Gentamicin therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Adult Dose for Bacterial Endocarditis Prophylaxis:

1.5 mg/kg (maximum 120 mg) IV or IM once within 30 minutes of starting the procedure
Comments: For high risk patients, in addition to Gentamicin (Alfamydex), ampicillin 2 g is given IV or IM 30 minutes prior to the procedure, followed by ampicillin 1 g IV/IM or amoxicillin 1 g orally 6 hours later. In penicillin-allergic patients, vancomycin 1 g is infused IV 1 to 2 hours prior to the procedure.

Usual Adult Dose for Bacterial Infection:

1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours, or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: 7 to 21 days, depending on the nature and severity of the infection
Comments: Limiting the duration of Gentamicin therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Adult Dose for Brucellosis:

2 mg/kg loading dose, followed by 1.7 mg/kg IV or IM every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: For the first 2 to 3 weeks of antibiotic therapy
Comments: Oral doxycycline or sulfamethoxazole/trimethoprim should be continued for at least 6 weeks.

Usual Adult Dose for Burns - External:

2 to 2.5 mg/kg loading dose, followed by 1.7 to 2 mg/kg IV every 8 hours
Duration of therapy: 10 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Cystic Fibrosis:

5 to 10 mg/kg/day in 2 to 4 divided doses
Duration of therapy: Parenteral therapy should be continued for about 14 to 21 days, depending on the nature and severity of the infection and improvement of pulmonary function.

Usual Adult Dose for Endocarditis:

American Heart Association recommendations:
Native valve infections due to highly penicillin-susceptible viridans Group streptococci and S bovis (MIC <=0.12 mcg/mL): 3 mg/kg IV or IM once every 24 hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 4 weeks
Native valve infections due to relatively penicillin-resistant S viridans and S bovis (MIC >0.12 mcg/mL and <=0.5 mcg/mL): 3 mg/kg IV or IM once every 24 hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 4 weeks
Prosthetic valve infections due to S viridans and S bovis: 3 mg/kg IV or IM once every 24 hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 6 weeks
Native valve infections due to staphylococci: 1.5 mg/kg IV or IM every 12 hours or 1 mg/kg every 8 hours, in combination with nafcillin, oxacillin, or cefazolin
Duration of therapy: 3 to 5 days; continue other antibiotic for 6 weeks
Prosthetic valve infections due to staphylococci: 1.5 mg/kg IV or IM every 12 hours or 1 mg/kg every 8 hours, in combination with nafcillin or oxacillin, plus rifampin, or vancomycin plus rifampin
Duration of therapy: 2 weeks; continue other antibiotics for at least 6 weeks
Native valve or prosthetic valve infections due to susceptible enterococci: 1 mg/kg IV or IM every 8 hours, in combination with ampicillin, aqueous penicillin G sodium, or vancomycin
Duration of therapy: 4 to 6 weeks; continue other antibiotic for 6 weeks
Native valve or prosthetic valve infections due to penicillin-resistant enterococci: 1 mg/kg IV or IM every 8 hours, in combination with ampicillin-sulbactam or vancomycin
Duration of therapy: 6 weeks
Comments: Refer to current published guidelines for detailed recommendations.

Usual Adult Dose for Endometritis:

2 mg/kg loading dose, followed by 1.5 mg/kg IV or IM every 8 hours
Duration of therapy: Parenteral therapy should be continued for at least 24 hours after the patient has remained afebrile, pain free, and the leukocyte count has normalized.

Usual Adult Dose for Febrile Neutropenia:

2 mg/kg loading dose, followed by 1.7 mg/kg IV every 8 hours
Duration of therapy: Once the patient is stable, afebrile for 24 hours, and the absolute neutrophil count is greater than 500/mm3, oral antibiotics may be substituted if antibiotic therapy is to be continued.

Usual Adult Dose for Intraabdominal Infection:

2 mg/kg loading dose, followed by 1.7 mg/kg IV every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: 14 days, depending on the nature and severity of the infection
Comments: Less toxic antibiotics may be substituted once the patient is stable for at least 48 hours.

Usual Adult Dose for Meningitis:

2 mg/kg loading dose, followed by 1.7 mg/kg IV or IM every 8 hours
Duration of therapy: Parenteral therapy should be continued for at least 1 week after the patient becomes afebrile and cerebrospinal fluid normalizes.

Usual Adult Dose for Osteomyelitis:

1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: 4 to 6 weeks, depending on the nature and severity of the infection; chronic osteomyelitis may require an additional 1 to 2 months of oral antibiotics
Comments: Limiting the duration of Gentamicin therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Adult Dose for Pelvic Inflammatory Disease:

2 mg/kg loading dose, followed by 1.5 mg/kg IV or IM every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Parenteral therapy should be continued for at least 24 hours after clinical improvement and should be followed by oral doxycycline or clindamycin for a total 14 day course.

Usual Adult Dose for Peritonitis:

IV: 2 mg/kg loading dose, followed by 1.7 mg/kg IV every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for about 14 days, depending on the nature and severity of the infection.
Comments: Limiting the duration of Gentamicin therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.
Intraperitoneally in CAPD patients: 0.6 to 0.75 mg/kg intraperitoneally once a day or 16 to 20 mg per every 2 L dialysate

Usual Adult Dose for Plague:

2 mg/kg loading dose, followed by 1.7 mg/kg IV or IM every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for about 10 to 14 days, depending on the nature and severity of the infection.
Comments: Limiting the duration of Gentamicin (Alfamydex) therapy may help limit toxicity. Once the patient's condition improves, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Adult Dose for Pneumonia:

2 mg/kg loading dose, followed by 1.7 mg/kg IV or IM every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for 14 to 21 days, depending on the nature and severity of the infection.
Comments: Limiting the duration of Gentamicin therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Adult Dose for Pyelonephritis:

2 mg/kg loading dose, followed by 1.7 mg/kg IV every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for about 7 to 14 days, depending on the nature and severity of the infection.
Comments: Limiting the duration of Gentamicin (Alfamydex) therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Adult Dose for Skin or Soft Tissue Infection:

1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for at least 10 to 14 days, or until 3 days postacute inflammation, depending on the nature and severity of the infection; for severe infections, such as diabetic soft tissue infections, 14 to 21 days of therapy may be required
Comments: Limiting the duration of Gentamicin therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Adult Dose for Surgical Prophylaxis:

1.5 to 2 mg/kg (maximum 120 mg) IV or IM once at induction of anesthesia

Usual Adult Dose for Tularemia:

1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for about 10 to 14 days, depending on the nature and severity of the infection.
Comments: Once the patient's condition improves, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Pediatric Dose for Bacterial Infection:

0 to 4 weeks, birthweight <1200 g: 2.5 mg/kg IV or IM every 18 to 24 hours
0 to 1 week, birthweight >=1200 g: 2.5 mg/kg IV or IM every 12 hours
1 to 4 weeks, birthweight 1200 to 2000 g: 2.5 mg/kg IV or IM every 8 to 12 hours
1 to 4 weeks, birthweight >=2000 g: 2.5 mg/kg IV or IM every 8 hours
>1 month: 1 to 2.5 mg/kg IV or IM every 8 hours

Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis:

1.5 mg/kg IV or IM once within 30 minutes of starting the procedure
Comments: For high risk patients, in addition to Gentamicin, ampicillin 50 mg/kg (maximum 2 g) is given IV or IM 30 minutes prior to the procedure, followed by ampicillin 25 mg/kg IV/IM or amoxicillin 25 mg/kg orally 6 hours later. In penicillin-allergic patients, vancomycin 20 mg/kg IV is infused over 1 to 2 hours instead of ampicillin/amoxicillin.

Usual Pediatric Dose for Endocarditis:

AHA recommendations:
Native valve infections due to highly penicillin-susceptible viridans Group streptococci and S bovis (MIC <=0.12 mcg/mL): 3 mg/kg IV or IM once every 24 hours or 1 mg/kg every 8 hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 4 weeks
Native valve infections due to relatively penicillin-resistant S viridans and S bovis (MIC >0.12 mcg/mL and <=0.5 mcg/mL): 3 mg/kg IV or IM once every 24 hours or 1 mg/kg every 8 hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 4 weeks
Prosthetic valve infections due to S viridans and S bovis: 3 mg/kg IV or IM once every 24 hours or 1 mg/kg every 8 hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 6 weeks
Native valve infections due to staphylococci: 1 mg/kg IV or IM every 8 hours, in combination with nafcillin, oxacillin, or cefazolin
Duration of therapy: 3 to 5 days; continue other antibiotic for 6 weeks
Prosthetic valve infections due to staphylococci: 1 mg/kg every 8 hours, in combination with nafcillin or oxacillin, plus rifampin, or vancomycin plus rifampin
Duration of therapy: 2 weeks; continue other antibiotics for at least 6 weeks
Native valve or prosthetic valve infections due to susceptible enterococci: 1 mg/kg IV or IM every 8 hours, in combination with ampicillin, aqueous penicillin G sodium, or vancomycin
Duration of therapy: 4 to 6 weeks; continue other antibiotic for 6 weeks
Native valve or prosthetic valve infections due to penicillin-resistant enterococci: 1 mg/kg IV or IM every 8 hours, in combination with ampicillin-sulbactam or vancomycin
Duration of therapy: 6 weeks
Comments: Refer to current published guidelines for detailed recommendations.

Usual Pediatric Dose for Surgical Prophylaxis:

2 mg/kg IV once at induction of anesthesia

Active ingredients: Dexamethasone/Gentamicin

Select the most affordable brand or generic drug

Strength	Quantity	Price, USD	Country
Dexa-Gentamicin
Dexagent-Ophthal
Dexagenta
Dexamytrex Ophtiole
Dexamytrex Ophtiole 5 mL		$4.58
Triactiv

References

Dailymed."Gentamicin sulfate: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Dailymed."Dexamethasone: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
"Dexamethasone". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Alfamydex - Frequently asked Questions

Can Alfamydex be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

How should I take Gentamicin (Alfamydex)?

If you are injecting Gentamicin (Alfamydex) at home, your healthcare provider will give you detailed instructions on how and where to inject the medication. If you do not understand these directions, do not attempt to inject the medication. Contact your healthcare provider for further instructions.

Do not use any Gentamicin (Alfamydex) that is discolored, has particles in it, or looks different from your previous doses. Throw away any unused Gentamicin (Alfamydex) after the amount of time determined by your pharmacist or doctor.

Adequate hydration is important during treatment with Gentamicin (Alfamydex). Fluids may be administered intravenously during treatment.

It is important that the medication be given on a regular schedule and for the entire amount of time prescribed by your doctor.

Gentamicin (Alfamydex) may cause damage to the kidneys and/or nerves. Kidney function and drug levels in the blood may be monitored with blood tests during treatment. Tell your doctor if you experience hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage.

Dispose of used needles and syringes in a puncture resistant container out of the reach of children.

Your healthcare provider will store Gentamicin (Alfamydex) as directed by the manufacturer or give you detailed storage instructions if you are storing the medication at home.

How should I take Dexamethasone (Alfamydex)?

You should not use this medication if you have a fungal infection anywhere in your body.

What other drugs will affect Gentamicin (Alfamydex)?

Other drugs, especially those that affect the kidneys, can interact with Gentamicin (Alfamydex) resulting in dangerous side effects and/or decreased effectiveness. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, without first talking to your doctor during treatment with Gentamicin (Alfamydex).

Who should not take Dexamethasone (Alfamydex)?

You should not use this medication if you are allergic to Dexamethasone (Alfamydex) or sulfites, or if you have a fungal infection anywhere in your body.

Steroid medication can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Before using this medication, tell your doctor about any illness or infection you have had within the past several weeks.

To make sure Dexamethasone (Alfamydex) is safe for you, tell your doctor if you have:

tuberculosis;
cirrhosis or other liver disease;
kidney disease;
a thyroid disorder;
a history of malaria;
osteoporosis;
a muscle disorder such as myasthenia gravis;
glaucoma or cataracts;
herpes infection of the eyes;
stomach ulcers, ulcerative colitis, or diverticulitis;
depression or mental illness;
congestive heart failure;
high blood pressure; or
if you have recently had a heart attack.

FDA pregnancy category C. It is not known whether Dexamethasone (Alfamydex) will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Dexamethasone (Alfamydex) can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Steroids can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

What other drugs will affect Dexamethasone (Alfamydex)?

Many drugs can interact with Dexamethasone (Alfamydex). This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Dexamethasone (Alfamydex). Give a list of all your medicines to any healthcare provider who treats you.

Who should not take Gentamicin (Alfamydex)?

Do not use Gentamicin (Alfamydex) without first talking to your doctor if you have

sulfite sensitivity;
kidney disease;
hearing loss or loss of balance due to ear problems;
Parkinson's disease; or
a neuromuscular disorder such as myasthenia gravis.

You may not be able to use Gentamicin (Alfamydex), or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Do not use Gentamicin (Alfamydex) without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Do not use Gentamicin (Alfamydex) without first talking to your doctor if you are breast-feeding a baby.

Can Alfamydex be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Alfamydex be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on Alfamydex, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Alfamydex. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.