acetaminophen and diphenhydramine is a pain reliever and a fever reducer. Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Acetaminophen and diphenhydramine is a combination medicine used to treat headache, runny nose, sneezing, watery eyes, and pain or fever caused by allergies, the common cold, or the flu. acetaminophen and diphenhydramine may also be used for purposes not listed in acetaminophen and diphenhydramine guide.
Acetaminophen and diphenhydramine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. In rare cases, acetaminophen and diphenhydramine may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen and diphenhydramine in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen and diphenhydramine. Stop using the medicine and call your doctor at once if you have:
fast, pounding, or uneven heartbeats;
severe dizziness or drowsiness, slow or shallow breathing;
tremor, restless muscle movements;
little or no urinating;
flu symptoms, easy bruising, unusual bleeding, pale skin, feeling light-headed; or
nausea, pain in your upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
constipation;
dry eyes, blurred vision, dry mouth or nose;
mild dizziness or drowsiness, trouble concentrating;
feeling restless or excited (especially in children); or
mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects (in more detail)
Acetaminophen and diphenhydramine dosing
Usual Adult Dose for Insomnia:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine at bedtime. Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Adult Dose for Pain:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime. Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Adult Dose for Headache:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine at bedtime. Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Insomnia:
Greater than or equal to 12 years: Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime. Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Pain:
Greater than or equal to 12 years: Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine at bedtime. Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Headache:
Greater than or equal to 12 years: Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime. Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Dailymed."Acetaminophen; aspirin; caffeine: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Acetaminophen and diphenhydramine - Frequently asked Questions
Can Acetaminophen and diphenhydramine be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
Who should not take acetaminophen and diphenhydramine?
Ask a doctor before taking medicine that contains acetaminophen and diphenhydramine if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.
You should not use this medication if you are allergic to it, or if you have:
severe constipation, blockage in your stomach or intestines;
untreated or uncontrolled diseases--glaucoma, asthma, heart disease, overactive thyroid; or
if you are unable to urinate.
Ask a doctor or pharmacist before taking this medicine if you have any medical condition, especially:
kidney disease;
cough with mucus, or cough caused by emphysema or chronic bronchitis;
an enlarged prostate, problems with urination;
a history of alcoholism; or
if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).
It is not known whether this medicine will harm an unborn baby. Do not use cold or allergy medicine without a doctor's advice if you are pregnant.
This medicine can pass into breast milk and may harm a nursing baby. Antihistamines may slow breast milk production. Do not use cold or allergy without a doctor's advice if you are breast-feeding a baby.
Always ask a doctor before giving a cold or allergy medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
How should I take acetaminophen and diphenhydramine?
Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not take this medicine for longer than recommended. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up.
Do not take more of this medication than is recommended. An overdose of acetaminophen and diphenhydramine can damage your liver or cause death.
Stop taking the medicine and call your doctor if you still have a fever after 3 days, or you still have pain after 10 days. Also call your doctor if your symptoms get worse, or if you have any redness or swelling.
If you need surgery or medical tests, tell the doctor ahead of time if you have taken this medicine within the past few days.
Store at room temperature away from moisture and heat.
What other drugs will affect acetaminophen and diphenhydramine?
Other drugs may interact with acetaminophen and diphenhydramine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Can Acetaminophen and diphenhydramine be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Acetaminophen and diphenhydramine be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
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